L-arginine-induced experimental acute pancreatitis
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چکیده
Different animal models of experimental acute pancreatitis induced by caerulein, choline deficient ethionine supplemented (CDE) diet, or sodium taurocholate have been developed. These models vary in severity and have been used by the investigators to either understand the pathophysiological mechanism of the disease or to study the effect of different therapeutic agents. Mizunuma et al (18) were first to report that intraperitoneal (i.p.) administration of excessive doses of L-arginine (500 mg/100 g body weight) in rats selectively damage pancreatic acinar cells without any morphological change in islets of Langerhans or other organs. Based upon this observation, Tani et al (27) reported an L-arginine induced rat model of necrotizing acute pancreatitis. The dose used in this model was 500 mg/100 g. Doses higher than 500 mg/100 g body weight caused very high mortality. A single dose of 500 mg/100 g injected i.p. resulted in 70-80% of pancreatic acinar cell necrosis within 3 days. Since these observations, the model of L-arginine induced acute pancreatitis in rat has been used in different laboratories. The dose as well as frequency of administration has been varied. The different doses and frequencies of administration of Larginine evaluated in rat by different investigators have been reviewed by Hegyi et al (15) and are summarized below:
منابع مشابه
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تاریخ انتشار 2014